Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. [electronic resource]
- Scientific reports Jul 2015
- 12007 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep12007 doi
Androgen Receptor Antagonists--pharmacology Androgens--physiology Animals Antineoplastic Agents--pharmacokinetics Cell Line, Tumor Drug Resistance, Neoplasm HEK293 Cells Humans Male Mice, Inbred BALB C Mice, Nude Prostatic Neoplasms--drug therapy Pyrazoles--pharmacokinetics Receptors, Androgen--metabolism Signal Transduction Tumor Burden--drug effects Xenograft Model Antitumor Assays