Alsamarah, Abdelaziz

Uncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity. [electronic resource] - PloS one 2015 - e0132221 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0132221 doi


Activin Receptors, Type I--antagonists & inhibitors
Adenosine Triphosphate--metabolism
Amino Acid Motifs
Amino Acid Substitution
Binding Sites--drug effects
Bone Morphogenetic Protein Receptors, Type I--antagonists & inhibitors
Crystallography, X-Ray
Drug Design
Humans
Ligands
Molecular Docking Simulation
Molecular Dynamics Simulation
Molecular Structure
Point Mutation
Protein Conformation
Protein Kinase Inhibitors--chemistry
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein Structure, Tertiary
Pyrazoles--chemistry
Pyrimidines--chemistry
Quinolines--chemistry
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta--antagonists & inhibitors
Substrate Specificity
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors