Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. [electronic resource]
- PloS one 2015
- e0131207 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0131207 doi
AMP-Activated Protein Kinases--metabolism Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Breast Neoplasms--metabolism Cell Cycle--drug effects Epithelial-Mesenchymal Transition--drug effects Female Humans Hypoglycemic Agents--pharmacology MAP Kinase Signaling System--drug effects MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Phenformin--pharmacology Ribosomal Protein S6 Kinases, 70-kDa--metabolism TOR Serine-Threonine Kinases--metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays