TY  - GEN
AU  - Farina,Roberta
AU  - Pisani,Leonardo
AU  - Catto,Marco
AU  - Nicolotti,Orazio
AU  - Gadaleta,Domenico
AU  - Denora,Nunzio
AU  - Soto-Otero,Ramon
AU  - Mendez-Alvarez,Estefania
AU  - Passos,Carolina S
AU  - Muncipinto,Giovanni
AU  - Altomare,Cosimo D
AU  - Nurisso,Alessandra
AU  - Carrupt,Pierre-Alain
AU  - Carotti,Angelo
TI  - Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases
SN  - 1520-4804
PY  - 2015///1012
KW  - Animals
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - Cholinesterase Inhibitors
KW  - chemistry
KW  - Cholinesterases
KW  - Coumarins
KW  - Dogs
KW  - Drug Design
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Madin Darby Canine Kidney Cells
KW  - Molecular Docking Simulation
KW  - Monoamine Oxidase
KW  - Monoamine Oxidase Inhibitors
KW  - Permeability
KW  - Protein Conformation
KW  - Rats
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.5b00599
ER  -