Farina, Roberta <br/><br/>
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2015 
 - 5561-78 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b00599  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Blood-Brain Barrier--metabolism<br/>Cholinesterase Inhibitors--chemistry<br/>Cholinesterases--chemistry<br/>Coumarins--chemistry<br/>Dogs<br/>Drug Design<br/>Humans<br/>Inhibitory Concentration 50<br/>Madin Darby Canine Kidney Cells<br/>Molecular Docking Simulation<br/>Monoamine Oxidase--chemistry<br/>Monoamine Oxidase Inhibitors--chemistry<br/>Permeability<br/>Protein Conformation<br/>Rats<br/>Structure-Activity Relationship