TY  - GEN
AU  - Christie,Jason D
AU  - Vaslef,Steven
AU  - Chang,Philip K
AU  - May,Addison K
AU  - Gunn,Scott R
AU  - Yang,Shuying
AU  - Hardes,Kelly
AU  - Kahl,Lesley
AU  - Powley,William M
AU  - Lipson,David A
AU  - Bayliffe,Andrew I
AU  - Lazaar,Aili L
TI  - A Randomized Dose-Escalation Study of the Safety and Anti-Inflammatory Activity of the p38 Mitogen-Activated Protein Kinase Inhibitor Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome
SN  - 1530-0293
PY  - 2015///1104
KW  - Adult
KW  - C-Reactive Protein
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Double-Blind Method
KW  - Female
KW  - Hospital Mortality
KW  - Humans
KW  - Inflammation Mediators
KW  - metabolism
KW  - Interleukin-6
KW  - biosynthesis
KW  - Interleukin-8
KW  - Male
KW  - Middle Aged
KW  - Pyridones
KW  - administration & dosage
KW  - Pyrimidines
KW  - Receptors, Tumor Necrosis Factor, Type I
KW  - Respiratory Distress Syndrome
KW  - prevention & control
KW  - Trauma Severity Indices
KW  - Wounds and Injuries
KW  - drug therapy
KW  - p38 Mitogen-Activated Protein Kinases
KW  - antagonists & inhibitors
N1  - Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1097/CCM.0000000000001132
ER  -