Tedeschi, Philip M

Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development. [electronic resource] - Molecular cancer research : MCR Oct 2015 - 1361-6 p. digital

Publication Type: Journal Article

1557-3125

10.1158/1541-7786.MCR-15-0117 doi


Aminohydrolases--biosynthesis
Animals
Antineoplastic Agents--chemistry
Cell Proliferation--drug effects
Drug Design
Humans
Methylenetetrahydrofolate Dehydrogenase (NADP)--biosynthesis
Mice
Mitochondria--enzymology
Models, Molecular
Molecular Targeted Therapy
Multienzyme Complexes--biosynthesis
Neoplasms--drug therapy
Protein Conformation
Protein Folding
Structure-Activity Relationship