Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development. [electronic resource]
- Molecular cancer research : MCR Oct 2015
- 1361-6 p. digital
Publication Type: Journal Article
1557-3125
10.1158/1541-7786.MCR-15-0117 doi
Aminohydrolases--biosynthesis Animals Antineoplastic Agents--chemistry Cell Proliferation--drug effects Drug Design Humans Methylenetetrahydrofolate Dehydrogenase (NADP)--biosynthesis Mice Mitochondria--enzymology Models, Molecular Molecular Targeted Therapy Multienzyme Complexes--biosynthesis Neoplasms--drug therapy Protein Conformation Protein Folding Structure-Activity Relationship