TY  - GEN
AU  - Wu,Haodi
AU  - Lee,Jaecheol
AU  - Vincent,Ludovic G
AU  - Wang,Qingtong
AU  - Gu,Mingxia
AU  - Lan,Feng
AU  - Churko,Jared M
AU  - Sallam,Karim I
AU  - Matsa,Elena
AU  - Sharma,Arun
AU  - Gold,Joseph D
AU  - Engler,Adam J
AU  - Xiang,Yang K
AU  - Bers,Donald M
AU  - Wu,Joseph C
TI  - Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy
SN  - 1875-9777
PY  - 2016///0422
KW  - Adrenergic beta-Agonists
KW  - pharmacology
KW  - Cardiomyopathy, Dilated
KW  - genetics
KW  - Cell Differentiation
KW  - Cells, Cultured
KW  - Cyclic Nucleotide Phosphodiesterases, Type 2
KW  - Cyclic Nucleotide Phosphodiesterases, Type 3
KW  - Epigenesis, Genetic
KW  - Heart Rate
KW  - drug effects
KW  - Humans
KW  - Induced Pluripotent Stem Cells
KW  - Isoproterenol
KW  - Models, Cardiovascular
KW  - Mutant Proteins
KW  - Mutation
KW  - Myocardial Contraction
KW  - Myocytes, Cardiac
KW  - Receptors, Adrenergic, beta
KW  - metabolism
KW  - Signal Transduction
KW  - Troponin T
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.stem.2015.04.020
ER  -