TY  - GEN
AU  - Letavic,Michael A
AU  - Bonaventure,Pascal
AU  - Carruthers,Nicholas I
AU  - Dugovic,Christine
AU  - Koudriakova,Tatiana
AU  - Lord,Brian
AU  - Lovenberg,Timothy W
AU  - Ly,Kiev S
AU  - Mani,Neelakandha S
AU  - Nepomuceno,Diane
AU  - Pippel,Daniel J
AU  - Rizzolio,Michele
AU  - Shelton,Jonathan E
AU  - Shah,Chandra R
AU  - Shireman,Brock T
AU  - Young,Lana K
AU  - Yun,Sujin
TI  - Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate
SN  - 1520-4804
PY  - 2015///1012
KW  - Animals
KW  - Clinical Trials as Topic
KW  - Dogs
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - antagonists & inhibitors
KW  - Male
KW  - Neuropeptides
KW  - Orexin Receptors
KW  - metabolism
KW  - Orexins
KW  - Pyrroles
KW  - chemistry
KW  - Rats
KW  - Sleep Initiation and Maintenance Disorders
KW  - drug therapy
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.5b00742
ER  -