Letavic, Michael A <br/><br/>
Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2015 
 - 5620-36 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b00742  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Clinical Trials as Topic<br/>Dogs<br/>Humans<br/>Intracellular Signaling Peptides and Proteins--antagonists & inhibitors<br/>Male<br/>Neuropeptides--antagonists & inhibitors<br/>Orexin Receptors--metabolism<br/>Orexins<br/>Pyrroles--chemistry<br/>Rats<br/>Sleep Initiation and Maintenance Disorders--drug therapy<br/>Structure-Activity Relationship<br/>Substrate Specificity