TY - GEN AU - Chang,Leifu AU - Zhang,Ziguo AU - Yang,Jing AU - McLaughlin,Stephen H AU - Barford,David TI - Atomic structure of the APC/C and its mechanism of protein ubiquitination SN - 1476-4687 PY - 2015///0727 KW - Anaphase-Promoting Complex-Cyclosome KW - chemistry KW - Antigens, CD KW - Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome KW - Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome KW - Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome KW - Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome KW - Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome KW - Cadherins KW - Catalytic Domain KW - Cell Cycle Proteins KW - Cryoelectron Microscopy KW - Cytoskeletal Proteins KW - F-Box Proteins KW - Humans KW - Lysine KW - metabolism KW - Models, Molecular KW - Phosphorylation KW - Protein Binding KW - Protein Subunits KW - Structure-Activity Relationship KW - Substrate Specificity KW - Ubiquitin KW - Ubiquitin-Conjugating Enzymes KW - Ubiquitination N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nature14471 ER -