TY  - GEN
AU  - Tomar,Sakshi
AU  - Johnston,Melanie L
AU  - St John,Sarah E
AU  - Osswald,Heather L
AU  - Nyalapatla,Prasanth R
AU  - Paul,Lake N
AU  - Ghosh,Arun K
AU  - Denison,Mark R
AU  - Mesecar,Andrew D
TI  - Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
SN  - 1083-351X
PY  - 2015///1105
KW  - Amino Acid Sequence
KW  - Antiviral Agents
KW  - chemical synthesis
KW  - Coronavirus 3C Proteases
KW  - Crystallography, X-Ray
KW  - Cysteine Endopeptidases
KW  - chemistry
KW  - Escherichia coli
KW  - genetics
KW  - Gene Expression
KW  - Hydrophobic and Hydrophilic Interactions
KW  - Kinetics
KW  - Ligands
KW  - Middle East Respiratory Syndrome Coronavirus
KW  - drug effects
KW  - Molecular Docking Simulation
KW  - Molecular Sequence Data
KW  - Peptidomimetics
KW  - Protein Multimerization
KW  - Recombinant Proteins
KW  - Sequence Alignment
KW  - Substrate Specificity
KW  - Viral Proteins
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1074/jbc.M115.651463
ER  -