TY  - GEN
AU  - Christner,Susan M
AU  - Clausen,Dana M
AU  - Beumer,Jan H
AU  - Parise,Robert A
AU  - Guo,Jianxia
AU  - Huang,Yijun
AU  - Dömling,Alexander S
AU  - Eiseman,Julie L
TI  - In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction
SN  - 1432-0843
PY  - 2015///1013
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Drug Screening Assays, Antitumor
KW  - Female
KW  - HCT116 Cells
KW  - Heterografts
KW  - Humans
KW  - Mice, SCID
KW  - Neoplasm Transplantation
KW  - Proto-Oncogene Proteins
KW  - metabolism
KW  - Proto-Oncogene Proteins c-mdm2
KW  - Pyrazoles
KW  - Tumor Suppressor Protein p53
KW  - Ubiquitin-Protein Ligases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s00280-015-2791-y
ER  -