Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. [electronic resource]
- Toxicology and applied pharmacology Aug 2015
- 86-92 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1096-0333
10.1016/j.taap.2015.05.011 doi
Alanine Transaminase--blood Animals Antineoplastic Agents--administration & dosage Aptamers, Nucleotide--administration & dosage Aspartate Aminotransferases--blood Biomarkers--blood Chemical and Drug Induced Liver Injury--blood Complement C3a--metabolism Complement C5a--metabolism Cytokines--blood Dose-Response Relationship, Drug Drug Administration Schedule E-Selectin--drug effects Female Injections, Intravenous Kidney--drug effects Liver--drug effects Male Mice, Inbred ICR Necrosis Risk Assessment