Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds. [electronic resource]
- Archives of toxicology May 2016
- 1225-37 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
1432-0738
10.1007/s00204-015-1541-6 doi
Animals Biological Assay--methods Biological Transport Cell Differentiation--drug effects Cell Line Cell Survival--drug effects Dose-Response Relationship, Drug Embryonic Stem Cells--drug effects Female Fetus--drug effects Gestational Age Humans Kinetics Maternal Exposure Mice Models, Biological Pregnancy Rats Rats, Wistar Reproducibility of Results Risk Assessment Triazoles--metabolism Trophoblasts--metabolism