TY  - GEN
AU  - Winter,Georg E
AU  - Buckley,Dennis L
AU  - Paulk,Joshiawa
AU  - Roberts,Justin M
AU  - Souza,Amanda
AU  - Dhe-Paganon,Sirano
AU  - Bradner,James E
TI  - DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
SN  - 1095-9203
PY  - 2015///0707
KW  - Adaptor Proteins, Signal Transducing
KW  - Animals
KW  - Azepines
KW  - chemistry
KW  - Cell Cycle Proteins
KW  - Cell Line, Tumor
KW  - Crystallography, X-Ray
KW  - Disease Models, Animal
KW  - Drug Design
KW  - Leukemia, Promyelocytic, Acute
KW  - drug therapy
KW  - Ligands
KW  - Mice
KW  - Molecular Targeted Therapy
KW  - Nuclear Proteins
KW  - antagonists & inhibitors
KW  - Peptide Hydrolases
KW  - metabolism
KW  - Phthalimides
KW  - Protein Stability
KW  - drug effects
KW  - Protein Structure, Tertiary
KW  - Proteolysis
KW  - Tacrolimus Binding Protein 1A
KW  - Thalidomide
KW  - analogs & derivatives
KW  - Transcription Factors
KW  - Ubiquitin-Protein Ligases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/science.aab1433
ER  -