Winter, Georg E <br/><br/>
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.  [electronic resource] 

 -  Science (New York, N.Y.)  Jun 2015 
 - 1376-81 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1095-9203 
<br/><br/><label>Standard No.: </label>10.1126/science.aab1433  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adaptor Proteins, Signal Transducing<br/>Animals<br/>Azepines--chemistry<br/>Cell Cycle Proteins<br/>Cell Line, Tumor<br/>Crystallography, X-Ray<br/>Disease Models, Animal<br/>Drug Design<br/>Leukemia, Promyelocytic, Acute--drug therapy<br/>Ligands<br/>Mice<br/>Molecular Targeted Therapy<br/>Nuclear Proteins--antagonists & inhibitors<br/>Peptide Hydrolases--metabolism<br/>Phthalimides--chemistry<br/>Protein Stability--drug effects<br/>Protein Structure, Tertiary<br/>Proteolysis--drug effects<br/>Tacrolimus Binding Protein 1A--metabolism<br/>Thalidomide--analogs & derivatives<br/>Transcription Factors--antagonists & inhibitors<br/>Ubiquitin-Protein Ligases--metabolism