TY - GEN AU - Clarke,Michael O AU - Mackman,Richard AU - Byun,Daniel AU - Hui,Hon AU - Barauskas,Ona AU - Birkus,Gabriel AU - Chun,Byoung-Kwon AU - Doerffler,Edward AU - Feng,Joy AU - Karki,Kapil AU - Lee,Gary AU - Perron,Michel AU - Siegel,Dustin AU - Swaminathan,Swami AU - Lee,William TI - Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases SN - 1464-3405 PY - 2016///0223 KW - Adenosine KW - chemical synthesis KW - Antiviral Agents KW - Aza Compounds KW - chemistry KW - DNA-Directed DNA Polymerase KW - Drug Evaluation, Preclinical KW - Nucleic Acid Synthesis Inhibitors KW - RNA KW - RNA, Mitochondrial KW - RNA-Dependent RNA Polymerase KW - antagonists & inhibitors KW - Respiratory Syncytial Viruses KW - drug effects KW - Structure-Activity Relationship KW - Virus Replication N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bmcl.2015.04.073 ER -