TY  - GEN
AU  - Tanaka,Ryoichi
AU  - Tomosugi,Mitsuhiro
AU  - Horinaka,Mano
AU  - Sowa,Yoshihiro
AU  - Sakai,Toshiyuki
TI  - Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells
SN  - 1932-6203
PY  - 2016///0202
KW  - Antineoplastic Agents
KW  - toxicity
KW  - Apoptosis
KW  - drug effects
KW  - Apoptosis Regulatory Proteins
KW  - metabolism
KW  - Bcl-2-Like Protein 11
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Cyclin-Dependent Kinase Inhibitor p27
KW  - Down-Regulation
KW  - Drug Resistance, Neoplasm
KW  - G1 Phase Cell Cycle Checkpoints
KW  - Humans
KW  - Membrane Proteins
KW  - Metformin
KW  - MicroRNAs
KW  - antagonists & inhibitors
KW  - Oligonucleotides, Antisense
KW  - Pancreatic Neoplasms
KW  - Proto-Oncogene Proteins
KW  - Receptors, TNF-Related Apoptosis-Inducing Ligand
KW  - TNF-Related Apoptosis-Inducing Ligand
KW  - Tumor Suppressor Protein p53
KW  - genetics
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0125779
ER  -