Sadowski, Samira M <br/><br/>
Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis.  [electronic resource] 

 -  Oncotarget  Jul 2015 
 - 18038-49 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Intramural 
<br/><br/><label>ISSN: </label>1949-2553 
<br/><br/><label>Standard No.: </label>10.18632/oncotarget.3833  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adaptor Proteins, Signal Transducing--metabolism<br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Caspases--metabolism<br/>Cell Cycle Proteins<br/>Cell Line, Tumor<br/>Cell Movement--drug effects<br/>Cell Proliferation--drug effects<br/>Dose-Response Relationship, Drug<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>High-Throughput Screening Assays<br/>Humans<br/>Inhibitor of Apoptosis Proteins--metabolism<br/>Mice, Inbred NOD<br/>Molecular Targeted Therapy<br/>Naphthyridines--pharmacology<br/>Neoplasm Invasiveness<br/>Phosphoproteins--metabolism<br/>Phosphorylation<br/>Protein Kinase Inhibitors--pharmacology<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Ribosomal Protein S6 Kinases, 70-kDa--metabolism<br/>Signal Transduction--drug effects<br/>Survivin<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors<br/>Thyroid Carcinoma, Anaplastic--drug therapy<br/>Thyroid Neoplasms--drug therapy<br/>Time Factors<br/>Xenograft Model Antitumor Assays