TY - GEN AU - Sarkar,Ujjal AU - Rivera-Burgos,Dinelia AU - Large,Emma M AU - Hughes,David J AU - Ravindra,Kodihalli C AU - Dyer,Rachel L AU - Ebrahimkhani,Mohammad R AU - Wishnok,John S AU - Griffith,Linda G AU - Tannenbaum,Steven R TI - Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor SN - 1521-009X PY - 2016///0216 KW - Bioreactors KW - Coculture Techniques KW - Cytochrome P-450 CYP3A KW - metabolism KW - Cytokines KW - biosynthesis KW - Glucuronides KW - Half-Life KW - Hepatocytes KW - Humans KW - Hydrocortisone KW - Inflammation KW - chemically induced KW - Interleukin-5 KW - Kupffer Cells KW - Lipopolysaccharides KW - pharmacology KW - Liver KW - Tumor Necrosis Factor-alpha N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1124/dmd.115.063495 ER -