TY  - GEN
AU  - Drost,Jarno
AU  - van Jaarsveld,Richard H
AU  - Ponsioen,Bas
AU  - Zimberlin,Cheryl
AU  - van Boxtel,Ruben
AU  - Buijs,Arjan
AU  - Sachs,Norman
AU  - Overmeer,René M
AU  - Offerhaus,G Johan
AU  - Begthel,Harry
AU  - Korving,Jeroen
AU  - van de Wetering,Marc
AU  - Schwank,Gerald
AU  - Logtenberg,Meike
AU  - Cuppen,Edwin
AU  - Snippert,Hugo J
AU  - Medema,Jan Paul
AU  - Kops,Geert J P L
AU  - Clevers,Hans
TI  - Sequential cancer mutations in cultured human intestinal stem cells
SN  - 1476-4687
PY  - 2016///0602
KW  - Aneuploidy
KW  - Animals
KW  - CRISPR-Cas Systems
KW  - Child
KW  - Child, Preschool
KW  - Colorectal Neoplasms
KW  - genetics
KW  - Female
KW  - Genes, APC
KW  - Genes, p53
KW  - Heterografts
KW  - Humans
KW  - Imidazoles
KW  - Intercellular Signaling Peptides and Proteins
KW  - metabolism
KW  - Intestinal Mucosa
KW  - Intestines
KW  - pathology
KW  - Mice
KW  - Middle Aged
KW  - Mutagenesis, Site-Directed
KW  - Mutation
KW  - Neoplasm Invasiveness
KW  - Neoplasm Transplantation
KW  - Organoids
KW  - Piperazines
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Smad4 Protein
KW  - deficiency
KW  - Stem Cell Niche
KW  - physiology
KW  - Stem Cells
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature14415
ER  -