Drost, Jarno <br/><br/>
Sequential cancer mutations in cultured human intestinal stem cells.  [electronic resource] 

 -  Nature  May 2015 
 - 43-7 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-4687 
<br/><br/><label>Standard No.: </label>10.1038/nature14415  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aneuploidy<br/>Animals<br/>CRISPR-Cas Systems<br/>Child<br/>Child, Preschool<br/>Colorectal Neoplasms--genetics<br/>Female<br/>Genes, APC<br/>Genes, p53--genetics<br/>Heterografts<br/>Humans<br/>Imidazoles<br/>Intercellular Signaling Peptides and Proteins--metabolism<br/>Intestinal Mucosa--metabolism<br/>Intestines--pathology<br/>Mice<br/>Middle Aged<br/>Mutagenesis, Site-Directed<br/>Mutation--genetics<br/>Neoplasm Invasiveness--genetics<br/>Neoplasm Transplantation<br/>Organoids--metabolism<br/>Piperazines<br/>Proto-Oncogene Proteins p21(ras)--genetics<br/>Smad4 Protein--deficiency<br/>Stem Cell Niche--physiology<br/>Stem Cells--metabolism