A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury. [electronic resource]
- British journal of pharmacology Aug 2015
- 3904-16 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5381
10.1111/bph.13178 doi
Animals Bleeding Time Blood Platelets--drug effects Brain Ischemia--metabolism Cell Count Cerebral Hemorrhage--prevention & control Crotalid Venoms--pharmacology Dose-Response Relationship, Drug Fibrin--metabolism Infarction, Middle Cerebral Artery Lectins, C-Type Male Mice Platelet Glycoprotein GPIb-IX Complex--antagonists & inhibitors Protective Agents--pharmacology Reperfusion Injury--prevention & control Stroke--pathology Tirofiban Tyrosine--analogs & derivatives von Willebrand Factor--metabolism