TY - GEN AU - McHugh,Colleen A AU - Chen,Chun-Kan AU - Chow,Amy AU - Surka,Christine F AU - Tran,Christina AU - McDonel,Patrick AU - Pandya-Jones,Amy AU - Blanco,Mario AU - Burghard,Christina AU - Moradian,Annie AU - Sweredoski,Michael J AU - Shishkin,Alexander A AU - Su,Julia AU - Lander,Eric S AU - Hess,Sonja AU - Plath,Kathrin AU - Guttman,Mitchell TI - The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 SN - 1476-4687 PY - 2015///0702 KW - Acetylation KW - Animals KW - Cell Line KW - DNA-Binding Proteins KW - Embryonic Stem Cells KW - enzymology KW - Female KW - Gene Silencing KW - Heterogeneous-Nuclear Ribonucleoprotein U KW - metabolism KW - Histone Deacetylases KW - Histones KW - Male KW - Mass Spectrometry KW - methods KW - Mice KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 2 KW - Polycomb Repressive Complex 2 KW - Protein Binding KW - RNA Polymerase II KW - RNA, Long Noncoding KW - genetics KW - RNA-Binding Proteins KW - analysis KW - Receptors, Cytoplasmic and Nuclear KW - Transcription, Genetic KW - X Chromosome KW - X Chromosome Inactivation KW - Lamin B Receptor N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nature14443 ER -