The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-propane-2-sulfonamide (PF-04958242). [electronic resource]
- Journal of medicinal chemistry May 2015
- 4291-308 p. digital
Publication Type: Journal Article
1520-4804
10.1021/acs.jmedchem.5b00300 doi
Administration, Oral Adolescent Adult Aged Animals Binding Sites Disease Models, Animal Dogs Dose-Response Relationship, Drug Drug Discovery Drug Evaluation, Preclinical--methods Drug Stability Female Humans Male Memory, Short-Term--drug effects Mice, Inbred C57BL Middle Aged Protein Conformation Rats, Sprague-Dawley Receptors, AMPA--metabolism Schizophrenia--drug therapy Structure-Activity Relationship Sulfonamides--chemistry Thiophenes--chemistry Young Adult