A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice. [electronic resource]
- Toxicology mechanisms and methods Mar 2015
- 229-33 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1537-6524
10.3109/15376516.2015.1036333 doi
Acetylcholinesterase--blood Animals Animals, Outbred Strains Antidotes--therapeutic use Atropine--therapeutic use Brain--drug effects Cholinesterase Inhibitors--administration & dosage Cholinesterase Reactivators--therapeutic use Diaphragm--drug effects Dose-Response Relationship, Drug Drug Therapy, Combination Male Mice Muscarinic Antagonists--therapeutic use Nerve Tissue Proteins--agonists Neurons--drug effects Neurotoxicity Syndromes--blood Obidoxime Chloride--therapeutic use Oximes--therapeutic use Pyridinium Compounds--therapeutic use Rats, Wistar Sarin--administration & dosage