Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells. [electronic resource]
- Molecular cancer therapeutics Jun 2015
- 1395-403 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-14-0915 doi
Antineoplastic Agents--pharmacology Apoptosis--drug effects Basic Helix-Loop-Helix Transcription Factors--genetics Blotting, Western Cell Line Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Dose-Response Relationship, Drug Flavonoids--pharmacology Gene Expression Regulation, Neoplastic--drug effects Homeodomain Proteins--genetics Humans Inhibitor of Apoptosis Proteins--genetics Pancreatic Neoplasms--genetics Propiophenones--pharmacology Receptor, Notch1--genetics Reverse Transcriptase Polymerase Chain Reaction Signal Transduction--drug effects Survivin Time Factors Transcription Factor HES-1 Tumor Stem Cell Assay