TY  - GEN
AU  - Bailly,A
AU  - Perrin,A
AU  - Bou Malhab,L J
AU  - Pion,E
AU  - Larance,M
AU  - Nagala,M
AU  - Smith,P
AU  - O'Donohue,M-F
AU  - Gleizes,P-E
AU  - Zomerdijk,J
AU  - Lamond,A I
AU  - Xirodimas,D P
TI  - The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway
SN  - 1476-5594
PY  - 2016///0620
KW  - Animals
KW  - Caenorhabditis elegans
KW  - cytology
KW  - Caenorhabditis elegans Proteins
KW  - Cell Line
KW  - drug effects
KW  - Cell Nucleolus
KW  - Cyclopentanes
KW  - pharmacology
KW  - Genes, p53
KW  - Humans
KW  - MCF-7 Cells
KW  - Metabolic Networks and Pathways
KW  - Mice, Mutant Strains
KW  - NEDD8 Protein
KW  - Proto-Oncogene Proteins c-mdm2
KW  - genetics
KW  - Pyrimidines
KW  - Ribosomal Proteins
KW  - Ribosomes
KW  - Ubiquitins
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/onc.2015.104
ER  -