Bailly, A <br/><br/>
The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.  [electronic resource] 

 -  Oncogene  Jan 2016 
 - 415-26 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-5594 
<br/><br/><label>Standard No.: </label>10.1038/onc.2015.104  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Caenorhabditis elegans--cytology<br/>Caenorhabditis elegans Proteins<br/>Cell Line--drug effects<br/>Cell Nucleolus--drug effects<br/>Cyclopentanes--pharmacology<br/>Genes, p53--drug effects<br/>Humans<br/>MCF-7 Cells--drug effects<br/>Metabolic Networks and Pathways--drug effects<br/>Mice, Mutant Strains<br/>NEDD8 Protein<br/>Proto-Oncogene Proteins c-mdm2--genetics<br/>Pyrimidines--pharmacology<br/>Ribosomal Proteins--genetics<br/>Ribosomes--drug effects<br/>Ubiquitins--antagonists & inhibitors