TY - GEN AU - Zhen,Xiao-Li AU - Yin,Wen-Hui AU - Tian,Xia AU - Ma,Zhen-Jie AU - Fan,Shi-Ming AU - Han,Jian-Rong AU - Liu,Shouxin TI - Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity SN - 1464-3391 PY - 2016///0126 KW - Acetylcholinesterase KW - chemistry KW - Catalytic Domain KW - Cathepsin B KW - antagonists & inhibitors KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Enzyme Assays KW - Enzyme Inhibitors KW - chemical synthesis KW - GPI-Linked Proteins KW - Gene Expression KW - HeLa Cells KW - Humans KW - IMP Dehydrogenase KW - Kinetics KW - Molecular Docking Simulation KW - Peptides, Cyclic KW - Proteasome Endopeptidase Complex KW - Protein Binding KW - Protein Tyrosine Phosphatase, Non-Receptor Type 11 KW - Structure-Activity Relationship N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.bmc.2015.03.035 ER -