TY  - GEN
AU  - Esapa,Christopher T
AU  - Hannan,Fadil M
AU  - Babinsky,Valerie N
AU  - Potter,Paul
AU  - Thomas,Gethin P
AU  - Croucher,Peter I
AU  - Brown,Matthew A
AU  - Brown,Steve D M
AU  - Cox,Roger D
AU  - Thakker,Rajesh V
TI  - N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models
SN  - 1932-6203
PY  - 2016///0331
KW  - Alleles
KW  - Amino Acid Sequence
KW  - Animals
KW  - COS Cells
KW  - Calcinosis
KW  - metabolism
KW  - Chlorocebus aethiops
KW  - Codon, Nonsense
KW  - Disease Models, Animal
KW  - Endoplasmic Reticulum
KW  - Ethylnitrosourea
KW  - toxicity
KW  - Fibroblast Growth Factor-23
KW  - Fibroblast Growth Factors
KW  - blood
KW  - Genetic Loci
KW  - Genotype
KW  - Glucuronidase
KW  - chemistry
KW  - Humans
KW  - Kidney
KW  - Klotho Proteins
KW  - Longevity
KW  - drug effects
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Molecular Sequence Data
KW  - Mutation, Missense
KW  - N-Acetylgalactosaminyltransferases
KW  - genetics
KW  - Phenotype
KW  - Phosphates
KW  - Polymorphism, Single Nucleotide
KW  - Sequence Alignment
KW  - Vitamin D
KW  - analogs & derivatives
KW  - Polypeptide N-acetylgalactosaminyltransferase
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0122650
ER  -