Lee, Sang Yoon

Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin. [electronic resource] - Toxicology letters Jun 2015 - 107-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-3169

10.1016/j.toxlet.2015.03.015 doi


Animals
Aryl Hydrocarbon Hydroxylases--biosynthesis
Constitutive Androstane Receptor
Cytochrome P-450 CYP3A--biosynthesis
Cytochrome P-450 CYP3A Inducers--pharmacology
Cytochrome P-450 Enzyme Inducers--pharmacology
Cytochrome P-450 Enzyme System--biosynthesis
Cytochrome P450 Family 2
Enzyme Induction
Glucuronosyltransferase--metabolism
Humans
Isoenzymes
Liver--drug effects
Male
Membrane Proteins--biosynthesis
Mice, Inbred C57BL
Mice, Transgenic
Microsomes, Liver--drug effects
Pregnane X Receptor
Receptors, Cytoplasmic and Nuclear--agonists
Receptors, Steroid--agonists
Rifampin--pharmacology
Steroid Hydroxylases--biosynthesis
Substrate Specificity
Time Factors