TY  - GEN
AU  - Nonami,Atsushi
AU  - Sattler,Martin
AU  - Weisberg,Ellen
AU  - Liu,Qingsong
AU  - Zhang,Jianming
AU  - Patricelli,Matthew P
AU  - Christie,Amanda L
AU  - Saur,Amy M
AU  - Kohl,Nancy E
AU  - Kung,Andrew L
AU  - Yoon,Hojong
AU  - Sim,Taebo
AU  - Gray,Nathanael S
AU  - Griffin,James D
TI  - Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach
SN  - 1528-0020
PY  - 2015///0805
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Bridged Bicyclo Compounds, Heterocyclic
KW  - Cell Cycle Checkpoints
KW  - Cell Line, Tumor
KW  - Disease Models, Animal
KW  - Drug Screening Assays, Antitumor
KW  - GTP Phosphohydrolases
KW  - genetics
KW  - Germinal Center Kinases
KW  - Humans
KW  - Leukemia
KW  - drug therapy
KW  - Membrane Proteins
KW  - Mice
KW  - Mutation
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Proto-Oncogene Proteins c-akt
KW  - metabolism
KW  - Pyrimidinones
KW  - Signal Transduction
KW  - Small Molecule Libraries
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1182/blood-2014-12-615906
ER  -