Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. [electronic resource]
- Blood May 2015
- 3133-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1528-0020
10.1182/blood-2014-12-615906 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Bridged Bicyclo Compounds, Heterocyclic--pharmacology Cell Cycle Checkpoints--drug effects Cell Line, Tumor Disease Models, Animal Drug Screening Assays, Antitumor GTP Phosphohydrolases--genetics Germinal Center Kinases Humans Leukemia--drug therapy Membrane Proteins--genetics Mice Mutation Protein Kinase Inhibitors--pharmacology Protein Serine-Threonine Kinases--antagonists & inhibitors Proto-Oncogene Proteins c-akt--metabolism Pyrimidinones--pharmacology Signal Transduction--drug effects Small Molecule Libraries Xenograft Model Antitumor Assays