Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy. [electronic resource]
- Oncotarget Apr 2015
- 9113-24 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.3272 doi
Animals Azacitidine--analogs & derivatives CpG Islands DNA Methylation--drug effects Decitabine Embryonic Development--genetics Gene Expression Regulation, Neoplastic--drug effects Genes, Tumor Suppressor Gestational Age Heterozygote Histones--metabolism Kruppel-Like Transcription Factors--metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Models, Genetic Mutation Neoplasm Proteins--biosynthesis Patched Receptors Patched-1 Receptor Polymorphism, Single Nucleotide Promoter Regions, Genetic--genetics Protein Processing, Post-Translational Receptors, Cell Surface--biosynthesis Rhabdomyosarcoma--genetics Signal Transduction Zinc Finger Protein GLI1