Prediction of gestational age-dependent induction of in vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Jun 2015
- 836-42 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
1521-009X
10.1124/dmd.114.062984 doi
Adolescent Adult Cell Line Cells, Cultured Cytochrome P-450 CYP3A--genetics Enzyme Induction Estradiol--blood Female Hepatocytes--cytology Human Growth Hormone--blood Humans Hydrocortisone--blood Models, Biological Osmolar Concentration Pregnancy--blood Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Progesterone--blood