TY  - GEN
AU  - Chen,Zhengshan
AU  - Shojaee,Seyedmehdi
AU  - Buchner,Maike
AU  - Geng,Huimin
AU  - Lee,Jae Woong
AU  - Klemm,Lars
AU  - Titz,Björn
AU  - Graeber,Thomas G
AU  - Park,Eugene
AU  - Tan,Ying Xim
AU  - Satterthwaite,Anne
AU  - Paietta,Elisabeth
AU  - Hunger,Stephen P
AU  - Willman,Cheryl L
AU  - Melnick,Ari
AU  - Loh,Mignon L
AU  - Jung,Jae U
AU  - Coligan,John E
AU  - Bolland,Silvia
AU  - Mak,Tak W
AU  - Limnander,Andre
AU  - Jumaa,Hassan
AU  - Reth,Michael
AU  - Weiss,Arthur
AU  - Lowell,Clifford A
AU  - Müschen,Markus
TI  - Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
SN  - 1476-4687
PY  - 2015///0702
KW  - Amino Acid Motifs
KW  - genetics
KW  - Animals
KW  - Antigens, CD
KW  - metabolism
KW  - B-Lymphocytes
KW  - drug effects
KW  - Cell Death
KW  - Cell Line, Tumor
KW  - Cell Transformation, Neoplastic
KW  - Disease Models, Animal
KW  - Drug Resistance, Neoplasm
KW  - Enzyme Activation
KW  - Female
KW  - Fusion Proteins, bcr-abl
KW  - Gene Deletion
KW  - Humans
KW  - Inositol Polyphosphate 5-Phosphatases
KW  - Intracellular Signaling Peptides and Proteins
KW  - agonists
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
KW  - Phosphoric Monoester Hydrolases
KW  - antagonists & inhibitors
KW  - Platelet Endothelial Cell Adhesion Molecule-1
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW  - drug therapy
KW  - Precursor Cells, B-Lymphoid
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 6
KW  - deficiency
KW  - Protein-Tyrosine Kinases
KW  - Receptors, Antigen, B-Cell
KW  - Receptors, Immunologic
KW  - Signal Transduction
KW  - Syk Kinase
KW  - Tyrosine
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature14231
ER  -