Chen, Zhengshan <br/><br/>
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.  [electronic resource] 

 -  Nature  May 2015 
 - 357-61 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-4687 
<br/><br/><label>Standard No.: </label>10.1038/nature14231  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Motifs--genetics<br/>Animals<br/>Antigens, CD--metabolism<br/>B-Lymphocytes--drug effects<br/>Cell Death--drug effects<br/>Cell Line, Tumor<br/>Cell Transformation, Neoplastic<br/>Disease Models, Animal<br/>Drug Resistance, Neoplasm--drug effects<br/>Enzyme Activation--drug effects<br/>Female<br/>Fusion Proteins, bcr-abl--genetics<br/>Gene Deletion<br/>Humans<br/>Inositol Polyphosphate 5-Phosphatases<br/>Intracellular Signaling Peptides and Proteins--agonists<br/>Mice<br/>Mice, Inbred NOD<br/>Mice, SCID<br/>Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases<br/>Phosphoric Monoester Hydrolases--antagonists & inhibitors<br/>Platelet Endothelial Cell Adhesion Molecule-1--metabolism<br/>Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy<br/>Precursor Cells, B-Lymphoid--drug effects<br/>Protein Tyrosine Phosphatase, Non-Receptor Type 6--deficiency<br/>Protein-Tyrosine Kinases--metabolism<br/>Receptors, Antigen, B-Cell--deficiency<br/>Receptors, Immunologic--genetics<br/>Signal Transduction--drug effects<br/>Syk Kinase<br/>Tyrosine--metabolism<br/>Xenograft Model Antitumor Assays