Niu, Ning-Kui <br/><br/>
Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.  [electronic resource] 

 -  Drug design, development and therapy  2015 
 - 1555-84 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1177-8881 
<br/><br/><label>Standard No.: </label>10.2147/DDDT.S74197  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--chemistry<br/>Apoptosis--drug effects<br/>Autophagy--drug effects<br/>Azepines--chemistry<br/>Cell Cycle--drug effects<br/>Cell Proliferation--drug effects<br/>Cell Survival--drug effects<br/>Dose-Response Relationship, Drug<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>MAP Kinase Signaling System--drug effects<br/>Mitochondria--drug effects<br/>Mitogen-Activated Protein Kinases--antagonists & inhibitors<br/>Molecular Structure<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Protein Kinase Inhibitors--chemistry<br/>Proto-Oncogene Proteins c-akt--antagonists & inhibitors<br/>Pyrimidines--chemistry<br/>Reactive Oxygen Species--metabolism<br/>Structure-Activity Relationship<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors<br/>Tumor Cells, Cultured