TY - GEN AU - Niederst,Matthew J AU - Sequist,Lecia V AU - Poirier,John T AU - Mermel,Craig H AU - Lockerman,Elizabeth L AU - Garcia,Angel R AU - Katayama,Ryohei AU - Costa,Carlotta AU - Ross,Kenneth N AU - Moran,Teresa AU - Howe,Emily AU - Fulton,Linnea E AU - Mulvey,Hillary E AU - Bernardo,Lindsay A AU - Mohamoud,Farhiya AU - Miyoshi,Norikatsu AU - VanderLaan,Paul A AU - Costa,Daniel B AU - Jänne,Pasi A AU - Borger,Darrell R AU - Ramaswamy,Sridhar AU - Shioda,Toshi AU - Iafrate,Anthony J AU - Getz,Gad AU - Rudin,Charles M AU - Mino-Kenudson,Mari AU - Engelman,Jeffrey A TI - RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer SN - 2041-1723 PY - 2016///0209 KW - Adenocarcinoma KW - drug therapy KW - Adenocarcinoma of Lung KW - Afatinib KW - Aniline Compounds KW - pharmacology KW - Antineoplastic Agents KW - Carcinoma, Non-Small-Cell Lung KW - Cell Line, Tumor KW - Disease Progression KW - Drug Resistance, Neoplasm KW - drug effects KW - ErbB Receptors KW - antagonists & inhibitors KW - Erlotinib Hydrochloride KW - Gefitinib KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Lung KW - Lung Neoplasms KW - Mutation KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins c-bcl-2 KW - genetics KW - Quinazolines KW - Recurrence KW - Retinoblastoma Protein KW - deficiency KW - Signal Transduction KW - Small Cell Lung Carcinoma KW - Sulfonamides KW - bcl-X Protein N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1038/ncomms7377 ER -