3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity. [electronic resource]
- Organic & biomolecular chemistry Apr 2015
- 4296-309 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1477-0539
10.1039/c5ob00233h doi
ATP Binding Cassette Transporter, Subfamily B--antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors Antineoplastic Agents--chemistry Benzodioxoles--chemistry Cell Line, Tumor Drug Resistance, Neoplasm--drug effects Drug Screening Assays, Antitumor Humans Models, Molecular Neovascularization, Pathologic--drug therapy Protein Conformation Quinolines--chemistry Structure-Activity Relationship Thiophenes--chemistry Vascular Endothelial Growth Factor Receptor-1--antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors