TY  - GEN
AU  - Kettle,Jason G
AU  - Ballard,Peter
AU  - Bardelle,Catherine
AU  - Cockerill,Mark
AU  - Colclough,Nicola
AU  - Critchlow,Susan E
AU  - Debreczeni,Judit
AU  - Fairley,Gary
AU  - Fillery,Shaun
AU  - Graham,Mark A
AU  - Goodwin,Louise
AU  - Guichard,Sylvie
AU  - Hudson,Kevin
AU  - Ward,Richard A
AU  - Whittaker,David
TI  - Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis
SN  - 1520-4804
PY  - 2015///0526
KW  - Animals
KW  - COS Cells
KW  - Cell Line, Tumor
KW  - Chlorocebus aethiops
KW  - Drug Discovery
KW  - Drug Resistance
KW  - Humans
KW  - MAP Kinase Kinase Kinases
KW  - antagonists & inhibitors
KW  - Models, Molecular
KW  - Protein Kinase Inhibitors
KW  - chemistry
KW  - Protein Serine-Threonine Kinases
KW  - Protein-Tyrosine Kinases
KW  - RNA Interference
KW  - RNA, Small Interfering
KW  - genetics
KW  - Rats, Wistar
KW  - Dyrk Kinases
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.5b00098
ER  -