Kettle, Jason G <br/><br/>
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.  [electronic resource] 

 -  Journal of medicinal chemistry  Mar 2015 
 - 2834-44 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b00098  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>COS Cells<br/>Cell Line, Tumor<br/>Chlorocebus aethiops<br/>Drug Discovery<br/>Drug Resistance<br/>Humans<br/>MAP Kinase Kinase Kinases--antagonists & inhibitors<br/>Models, Molecular<br/>Protein Kinase Inhibitors--chemistry<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>RNA Interference<br/>RNA, Small Interfering--genetics<br/>Rats, Wistar<br/>Dyrk Kinases