TY - GEN AU - Nishimura,Kazuho AU - Kumazawa,Takuya AU - Kuroda,Takao AU - Katagiri,Naohiro AU - Tsuchiya,Mai AU - Goto,Natsuka AU - Furumai,Ryohei AU - Murayama,Akiko AU - Yanagisawa,Junn AU - Kimura,Keiji TI - Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation SN - 2211-1247 PY - 2015///1125 KW - Animals KW - Cell Cycle Proteins KW - antagonists & inhibitors KW - Cell Nucleolus KW - metabolism KW - Cells, Cultured KW - Cellular Senescence KW - Humans KW - MCF-7 Cells KW - Mice KW - Nuclear Proteins KW - Proto-Oncogene Proteins c-mdm2 KW - genetics KW - RNA Interference KW - RNA, Ribosomal, 5S KW - RNA, Small Interfering KW - RNA-Binding Proteins KW - Ribosomal Proteins KW - Ribosomes KW - Transcriptional Activation KW - Tumor Suppressor Protein p53 KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.celrep.2015.01.055 ER -