Lin, Chin-Chung <br/><br/>
Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells.  [electronic resource] 

 -  Environmental toxicology  Aug 2016 
 - 957-69 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1522-7278 
<br/><br/><label>Standard No.: </label>10.1002/tox.22105  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents, Phytogenic--pharmacology<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--metabolism<br/>Bone Neoplasms--drug therapy<br/>Calcium Signaling<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>DNA Damage<br/>Drug Screening Assays, Antitumor<br/>Drugs, Chinese Herbal--pharmacology<br/>Endoplasmic Reticulum Chaperone BiP<br/>Humans<br/>Membrane Potential, Mitochondrial--drug effects<br/>Mitochondria--drug effects<br/>Osteosarcoma--drug therapy<br/>Protein Transport<br/>Reactive Oxygen Species--metabolism<br/>Rheum--chemistry<br/>S Phase Cell Cycle Checkpoints--drug effects