TY  - GEN
AU  - VanderVen,Brian C
AU  - Fahey,Ruth J
AU  - Lee,Wonsik
AU  - Liu,Yancheng
AU  - Abramovitch,Robert B
AU  - Memmott,Christine
AU  - Crowe,Adam M
AU  - Eltis,Lindsay D
AU  - Perola,Emanuele
AU  - Deininger,David D
AU  - Wang,Tiansheng
AU  - Locher,Christopher P
AU  - Russell,David G
TI  - Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
SN  - 1553-7374
PY  - 2016///0129
KW  - Adenylyl Cyclases
KW  - genetics
KW  - Animals
KW  - Antitubercular Agents
KW  - pharmacology
KW  - Bacterial Proteins
KW  - metabolism
KW  - Cell Line
KW  - Cholesterol
KW  - Cyclic AMP
KW  - Hydroxysteroid Dehydrogenases
KW  - antagonists & inhibitors
KW  - Intracellular Space
KW  - Lipid Metabolism
KW  - drug effects
KW  - Macrophages
KW  - immunology
KW  - Mice
KW  - Microbial Sensitivity Tests
KW  - Mixed Function Oxygenases
KW  - Mycobacterium tuberculosis
KW  - growth & development
KW  - Oxo-Acid-Lyases
KW  - Small Molecule Libraries
KW  - Tuberculosis, Pulmonary
KW  - drug therapy
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.ppat.1004679
ER  -