CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling. [electronic resource]
- Cancer research Apr 2015
- 1470-81 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-14-1589 doi
Animals Carcinoma, Hepatocellular--enzymology Cell Movement Cytochrome P-450 CYP3A--physiology Down-Regulation Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans Kaplan-Meier Estimate Liver Neoplasms--enzymology Lung Neoplasms--enzymology Mechanistic Target of Rapamycin Complex 2 Mice, Nude Multiprotein Complexes--metabolism Neoplasm Invasiveness Neoplasm Transplantation Prognosis Proportional Hazards Models Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt--metabolism Signal Transduction TOR Serine-Threonine Kinases--metabolism Tissue Inhibitor of Metalloproteinase-1--genetics Tissue Inhibitor of Metalloproteinase-2--genetics Transcriptional Activation