TY  - GEN
AU  - Zaveri,Nurulain T
AU  - Journigan,V Blair
AU  - Polgar,Willma E
TI  - Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors
SN  - 1948-7193
PY  - 2016///0104
KW  - Analgesics, Opioid
KW  - chemistry
KW  - Animals
KW  - CHO Cells
KW  - Cell Membrane
KW  - drug effects
KW  - Cricetulus
KW  - Dose-Response Relationship, Drug
KW  - Guanosine 5'-O-(3-Thiotriphosphate)
KW  - Humans
KW  - Models, Chemical
KW  - Molecular Structure
KW  - Narcotic Antagonists
KW  - chemical synthesis
KW  - Piperidines
KW  - Protein Binding
KW  - Receptors, Opioid
KW  - metabolism
KW  - Receptors, Opioid, delta
KW  - antagonists & inhibitors
KW  - Receptors, Opioid, kappa
KW  - Receptors, Opioid, mu
KW  - Sulfur Radioisotopes
KW  - Tetrahydroisoquinolines
KW  - Transfection
KW  - Nociceptin Receptor
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1021/cn500367b
ER  -