Design and synthesis of new bioisosteres of spirooxindoles (MI-63/219) as anti-breast cancer agents. [electronic resource]
- Bioorganic & medicinal chemistry Feb 2015
- 839-48 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1464-3391
10.1016/j.bmc.2014.12.037 doi
Animals Antineoplastic Agents--chemistry Breast--drug effects Breast Neoplasms--drug therapy Cell Line, Tumor Drug Design Female Humans Indoles--chemistry Mice, Nude Oxindoles Protein Interaction Maps--drug effects Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors Spiro Compounds--chemistry Tumor Suppressor Protein p53--antagonists & inhibitors